WWE Championship
- Batista (Week 01, July 2010 - Week 01, July 2010)
- Kofi Kingston (Night of Champions, July 2010 - Week 01, SmackDown!, September 2010) (Def. CM Punk)
- Drew McIntyre (Week 01, SmackDown!, September 2010 - Hell in a Cell, September 2010) (Def. Kofi Kingston)
- The Miz (Hell in a Cell, September 2010 - Hell in a Cell, September 2010) (Def. Drew McIntyre)
- Drew McIntyre (Hell in a Cell, September 2010 - Survivor Series, November 2010) (Def. the Miz)
- The Miz (Survivor Series, November 2010 - TLC: Tables, Ladders & Chairs, December 2010) (Def. Drew McIntyre)
- Edge (TLC: Tables, Ladders & Chairs, December 2010 - Week 02, SmackDown!, February 2011) (Def. the Miz)
- Drew McIntyre (Week 03, SmackDown!, February 2011 - Elimination Chamber, February 2011) (Vacated)
- Mark Henry (Elimination Chamber, February 2011 - Fatal 4-Way, May 2011) (Def. Drew McIntyre, the Miz, John Morrison, Ted DiBiase and Edge)
- CM Punk (Fatal 4-Way, May 2011 - Week 03, June 2011) (Def. Mark Henry, the Big Show and Randy Orton)
- Kane (Week 03, RAW, June 2011 - Money in the Bank, July 2011) (Def. CM Punk)
- CM Punk (Money in the Bank, July 2011 - WrestleMania XXVIII, April 2012) (Def. Kane)
- Stone Cold Steve Austin (SummerSlam, August 2011 - Week 03, RAW, August 2011) (Def. Brock Lesnar)
- Drew McIntyre (Week 03, RAW, August 2011 - Hell in a Cell, September 2011) (Def. Stone Cold Steve Austin)
- Stone Cold Steve Austin (Hell in a Cell, September 2011 - Absolute Zero, May 2012) (Def. Drew McIntyre)
- CM Punk (Absolute Zero, May 2012 - SummerSlam, August 2012) (Def. Stone Cold Steve Austin)
- Dolph Ziggler (SummerSlam, August 2012 - ) (Def. CM Punk)
World Heavyweight Championship
- John Cena (Week 01, July 2010 - SummerSlam, August 2010)
- Randy Orton (SummerSlam, August 2010 - Survivor Series, November 2010) (Def. John Cena and Chris Jericho)
- Triple H (Survivor Series, November 2010 - TLC: Tables, Ladders & Chairs, December 2010) (Def. Randy Orton)
- Randy Orton (TLC: Tables, Ladders & Chairs, December 2010 - Over the Limit, May 2011) (Def. Shawn Michaels and Triple H)
- Zack Ryder (Over the Limit, May 2011 - Fatal 4-Way, May 2011) (Def. John Cena and Randy Orton)
- Dolph Ziggler (Fatal 4-Way, May 2011 - Royal Rumble, January 2012) (Def. Rey Mysterio, John Cena and Zack Ryder)
- Edge (Royal Rumble, January 2012 - Week 02, Octane, June 2012) (Def. Dolph Ziggler)
- Vacant (Week 02, Octane, June 2012 - SummerSlam, August 2012) (Vacated)
- The Miz (SummerSlam, August 2012 - ) (Def. Christian via countout)
Intercontinental Championship
- Rey Mysterio (Week 01, July 2010 - Night of Champions, July 2010)
- Dolph Ziggler (Night of Champions, July 2010 - SummerSlam, August 2010) (Def. Rey Mysterio)
- Todo Americano (SummerSlam, August 2010 - Hell in a Cell, September 2010) (Def. Dolph Ziggler)
- Rey Mysterio (Hell in a Cell, September 2010 - Survivor Series, November 2010) (Def. Todo Americano and Dolph Ziggler)
- Christian (Survivor Series, November 2010 - TLC: Tables, Ladders & Chairs, December 2010) (Def. Rey Mysterio)
- Rey Mysterio (TLC: Tables, Ladders & Chairs, December 2010 - Week 04, RAW, January 2011) (Def. Christian and Kane)
- Tyson Kidd (Week 04, RAW, January 2011 - Week 01, SmackDown, May 2011) (Def. Rey Mysterio)
- Justin Gabriel (Week 01, SmackDown, May 2011 - Week 04, SmackDown, July 2011) (Def. Tyson Kidd)
- Zack Ryder (Week 04, SmackDown, July 2011 - Week 04, SmackDown, August 2011) (Def. Justin Gabriel)
- The Miz (Week 01, SmackDown, September 2011 - Week 03, RAW, September 2011) (Vacated)
- Zack Ryder (Week 03, RAW, September 2011 - Survivor Series, November 2011) (Def. the Miz)
- Daniel Bryan (Survivor Series, November 2011 - Aces High, June 2012) (Def. Zack Ryder and the Miz)
- Alberto Del Rio (Aces High, June 2012 - SummerSlam, August 2012) (Def. Daniel Bryan)
- Antonio Cesaro (SummerSlam, August 2012 - ) (Def. Alberto Del Rio and John Cena)
United States Championship
- Chris Jericho (Week 01, July 2010 - Night of Champions, July 2010)
- Edge (Night of Champions, July 2010 - Night of Champions, July 2010) (Vacated)
- The Big Show (Night of Champions, July 2010 - Week 02, October 2010) (Def. Edge)
- Evan Bourne (Week 02, SmackDown!, October 2010 - Week 04, SmackDown!, November 2010) (Def. the Big Show)
- R-Truth (Week 04, SmackDown!, November 2010 - Week 04, SmackDown!, March 2011) (Def. Evan Bourne)
- The Miz (Week 04, SmackDown!, March 2011 - Hell in a Cell, September 2011) (Def. R-Truth)
- Daniel Bryan (Hell in a Cell, September 2011 - Survivor Series, November 2011) (Def. the Miz) (Unified with Intercontinental Championship)
WWE Divas Championship
- LayCool (TLC: Tables, Ladders & Chairs, December 2010 - Week 01, RAW, March 2011)
- Layla (TLC: Tables, Ladders & Chairs, December 2010 - WrestleMania XXVII, April 2011)
- Kelly Kelly (Week 01, RAW, March 2011 - WrestleMania XXVII, April 2011) (Def. Michelle McCool)
- Layla (WrestleMania XXVII, April 2011 - Fatal 4-Way, May 2011) (Def. Kelly Kelly) (Unified)
- Michelle McCool (Fatal 4-Way, May 2011 - Night of Champions, June 2011) (Def. Eve Torres, Beth Phoenix and Layla)
- Kharma (Night of Champions, June 2011 - Hell in a Cell, September 2011) (Def. Michelle McCool)
- Trish Stratus (Hell in a Cell, September 2011 - SummerSlam, August 2012) (Def. Kharma)
- AJ Lee (SummerSlam, August 2012 - ) (Def. Trish Stratus)
WWE Women's Championship
- Beth Phoenix (Week 01, July 2010 - Night of Champions, July 2010)
- Natalya (Night of Champions, July 2010 - Week 01, RAW, September 2010) (Def. Beth Phoenix, Kelly Kelly, Nikki Bella and Brie Bella)
- Eve Torres (Week 01, RAW, September 2010 - Hell in a Cell, September 2010) (Def. Natalya, Gail Kim and Beth Phoenix)
- Natalya (Hell in a Cell, September 2010 - Survivor Series, November 2010) (Def. Eve Torres)
- Michelle McCool (Survivor Series, November 2010 - TLC: Tables, Ladders & Chairs, December 2010) (Def. Gail Kim, Kelly Kelly, Layla and Natalya) (Retired)
WWE Tag Team Championship
- William Regal & Finlay (Week 01, July 2010 - Night of Champions, July 2010)
- The Hart Dynasty (Night of Champions, July 2010 - Week 01, SmackDown!, September 2010) (Def. William Regal & Finlay)
- Santino Marella & R-Truth (Week 01, SmackDown!, September 2010 - Bragging Rights, October 2010) (Def. the Hart Dynasty)
- Sheamus & Dolph Ziggler (Bragging Rights, October 2010 - Week 02, RAW, December 2010) (Def. Santino Marella & R-Truth)
- John Cena (Week 02, RAW, December 2010 - Week 04, RAW, December 2010) (Def. Sheamus)
- John Cena & Zack Ryder (Week 04, RAW, December 2010 - Week 01, SmackDown!, March 2011)
- Red Black & Blue (Week 01, SmackDown!, March 2011 - Week 02, RAW, April 2011) (Def. Zack Ryder & John Cena)
- Kane & Goldust (Week 02, RAW, April 2011 - Night of Champions, June 2011) (Def. John Morrison & Jack Swagger)
- The Cartel (Night of Champions, June 2011 - Money in the Bank, July 2011) (Def. Kane & Goldust) Red Black & Blue (Money in the Bank, July 2011 - Week 03, RAW, August 2011) (Def. the Cartel)
- The Empire (Week 03, RAW, August 2011 - Tribute to the Troops, December 2011) (Def. Red Black & Blue)
- John Cena & Zack Ryder (Tribute to the Troops, December 2011 - ) (Def. the Empire)
- The Cartel (Week 01, Octane, March 2012 - WrestleMania XXVIII, April 2012) (Def. John Cena & Zack Ryder)
- The New Age Outlaws (WrestleMania XXVIII, April 2012 - Week 03, Octane, May 2012) (Def. the Cartel)
- The Empire (Week 03, Octane, May 2012 - ) (Def. the Cartel, Brood, Epico & Primo, the Big Valbroskis, the Godfather & Brodus Clay, the New Age Outlaws, Damien Sandow & Hunico, the Acolytes and the Usos)
- Vacant (SummerSlam, August 2012 - ) (Vacated)